# Depot One Comp PK ignoring BLQ observations.

[Generated automatically as a Fitting summary]

## Inputs

### Description

Name: | blq_pk_norm_fit_ignore
Title: | Depot One Comp PK ignoring BLQ observations.
Author: | J.R. Hartley
Abstract: |

Depot One Comp PK model, with BLQ (below level of quantification)
observations removed from data set.

Keywords: | tutorial; pk; advan4; dep_two_cmp; blq
Input Script: | `blq_pk_norm_fit_ignore.pyml`
Input Data: | `synthetic_data.csv`
Diagram: |

### Initial fixed effect estimates

    f[KA] = 1.0000
    f[CL] = 1.0000
    f[V1] = 20.0000
    f[KA_isv,CL_isv,V1_isv] = [
        [ 0.0500, 0.0100, 0.0100 ],
        [ 0.0100, 0.0500, 0.0100 ],
        [ 0.0100, 0.0100, 0.0500 ],
    ]
    f[PNOISE] = 0.1000
    f[ANOISE] = 0.0100

## Outputs

### Final objective value

    -829.6140

which required 1.30 iterations and took 188.86 seconds

### Final fitted fixed effects

    f[KA] = 0.2246
    f[CL] = 1.8588
    f[V1] = 52.6500
    f[KA_isv,CL_isv,V1_isv] = [
        [ 0.0000, -0.0002, 0.0008 ],
        [ -0.0002, 0.0203, -0.0066 ],
        [ 0.0008, -0.0066, 0.1603 ],
    ]
    f[PNOISE] = 0.1454
    f[ANOISE] = 0.0100

### Fitted parameter .csv files

Fixed Effects: | `fx_params.csv (fit)`
Random Effects: | `rx_params.csv (fit)`
Model params: | `mx_params.csv (fit)`
State values: | `sx_params.csv (fit)`
Predictions: | `px_params.csv (fit)`

## Plots

### Dense sim plots

Alternatively see All dense_sim graph plots

## Comparison

### Compare Main f[X]

Variable Name | Starting Value | Fitted Value | Prop Change | Abs Change
--- | --- | --- | --- | ---
f[KA] | 1.0000 | 0.2246 | 0.7754 | 0.7754
f[CL] | 1.0000 | 1.8588 | 0.8588 | 0.8588
f[V1] | 20.0000 | 52.6500 | 1.6325 | 32.6500

### Compare Noise f[X]

Variable Name | Starting Value | Fitted Value | Prop Change | Abs Change
--- | --- | --- | --- | ---
f[PNOISE] | 0.1000 | 0.1454 | 0.4536 | 0.0454

### Compare Variance f[X]

Variable Name | Starting Value | Fitted Value | Prop Change | Abs Change
--- | --- | --- | --- | ---
f[KA_isv] | 0.0500 | 0.0000 | 0.9998 | 0.0500
f[KA_isv;CL_isv] | 0.0100 | -0.0002 | 1.0201 | 0.0102
f[KA_isv;V1_isv] | 0.0100 | 0.0008 | 0.9205 | 0.0092
f[CL_isv;KA_isv] | 0.0100 | -0.0002 | 1.0201 | 0.0102
f[CL_isv] | 0.0500 | 0.0203 | 0.5946 | 0.0297
f[CL_isv;V1_isv] | 0.0100 | -0.0066 | 1.6605 | 0.0166
f[V1_isv;KA_isv] | 0.0100 | 0.0008 | 0.9205 | 0.0092
f[V1_isv;CL_isv] | 0.0100 | -0.0066 | 1.6605 | 0.0166
f[V1_isv] | 0.0500 | 0.1603 | 2.2059 | 0.1103