# Depot + One compartment PK with BLQ

[Generated automatically as a Fitting summary]

## Inputs

### Description

Name: | blq_pk
Title: | Depot + One compartment PK with BLQ
Author: | J.R. Hartley
Abstract: |

Depot One Comp PK model, with BLQ (below level of quantification) observations.

Keywords: | tutorial; pk; advan4; dep_two_cmp; blq
Input Script: | `blq_pk_fit.pyml`
Input Data: | `synthetic_data.csv`
Diagram: |

### Initial fixed effect estimates

    f[KA] = 1.0000
    f[CL] = 1.0000
    f[V1] = 20.0000
    f[KA_isv,CL_isv,V1_isv] = [
        [ 0.0500, 0.0100, 0.0100 ],
        [ 0.0100, 0.0500, 0.0100 ],
        [ 0.0100, 0.0100, 0.0500 ],
    ]
    f[PNOISE] = 0.1000
    f[ANOISE] = 0.0100

## Outputs

### Final objective value

    -727.7713

which required N. iterations and took 145.15 seconds

### Final fitted fixed effects

    f[KA] = 0.2224
    f[CL] = 1.9543
    f[V1] = 51.0073
    f[KA_isv,CL_isv,V1_isv] = [
        [ 0.0697, 0.0196, 0.0527 ],
        [ 0.0196, 0.0115, 0.0117 ],
        [ 0.0527, 0.0117, 0.1872 ],
    ]
    f[PNOISE] = 0.1473
    f[ANOISE] = 0.0100

### Fitted parameter .csv files

Fixed Effects: | `fx_params.csv (fit)`
Random Effects: | `rx_params.csv (fit)`
Model params: | `mx_params.csv (fit)`
State values: | `sx_params.csv (fit)`
Predictions: | `px_params.csv (fit)`

## Plots

### Dense sim plots

Alternatively see All dense_sim graph plots

## Comparison

### Compare Main f[X]

Variable Name | Fitted Value | Starting Value | Prop Change | Abs Change
--- | --- | --- | --- | ---
f[KA] | 0.2224 | 1.0000 | 0.7776 | 0.7776
f[CL] | 1.9543 | 1.0000 | 0.9543 | 0.9543
f[V1] | 51.0073 | 20.0000 | 1.5504 | 31.0073

### Compare Noise f[X]

Variable Name | Fitted Value | Starting Value | Prop Change | Abs Change
--- | --- | --- | --- | ---
f[PNOISE] | 0.1473 | 0.1000 | 0.4735 | 0.0473

### Compare Variance f[X]

Variable Name | Fitted Value | Starting Value | Prop Change | Abs Change
--- | --- | --- | --- | ---
f[KA_isv] | 0.0697 | 0.0500 | 0.3947 | 0.0197
f[KA_isv;CL_isv] | 0.0196 | 0.0100 | 0.9568 | 0.0096
f[KA_isv;V1_isv] | 0.0527 | 0.0100 | 4.2744 | 0.0427
f[CL_isv;KA_isv] | 0.0196 | 0.0100 | 0.9568 | 0.0096
f[CL_isv] | 0.0115 | 0.0500 | 0.7697 | 0.0385
f[CL_isv;V1_isv] | 0.0117 | 0.0100 | 0.1715 | 0.0017
f[V1_isv;KA_isv] | 0.0527 | 0.0100 | 4.2744 | 0.0427
f[V1_isv;CL_isv] | 0.0117 | 0.0100 | 0.1715 | 0.0017
f[V1_isv] | 0.1872 | 0.0500 | 2.7431 | 0.1372